Blog

Statins are among the most studied drugs in history. Rosuvastatin has the best LDL reduction per mg and the strongest cardiovascular evidence. Here's what the data actually shows.

Tadalafil is one of the most overlooked drugs in cardiovascular and longevity medicine. Its mechanism goes well beyond what it was FDA-approved for.

Both block DHT. Dutasteride is more potent. Here's what the clinical data shows and how to think about choosing between them.

Rapamycin is the only drug to consistently extend lifespan in multiple mammalian species. Here's what the science says and why longevity physicians are prescribing it now.

Low-dose oral minoxidil is now the preferred formulation for hair loss. It's more effective, easier to use, and doesn't require you to remember to apply anything to your scalp.

Tretinoin is the only topical skincare ingredient with robust clinical evidence for reversing photoaging. Everything else is trying to be this.

Metformin is the most-prescribed diabetes drug in the world. Longevity researchers think it may have anti-aging effects beyond glucose control. Here's the evidence and the ongoing trial.

Low dose naltrexone is one of the most cost-effective interventions in longevity medicine. It costs $0.30 to compound. Here's why clinics charge 30x that — and why you shouldn't pay it.

Acarbose extended lifespan by 22% in male mice in NIA Interventions Testing Program data. It's barely known outside research circles. Here's what it is and why longevity physicians are paying attention.

Semaglutide is known for dramatic weight loss. The SELECT trial showed it reduces cardiovascular events in people without diabetes. The longevity implications are significant.

The 2002 WHI study caused millions of women to stop or avoid HRT. The study was misrepresented. Here's what the actual evidence says.

Spironolactone is the primary pharmacological treatment for androgenetic alopecia in women. Here's the mechanism, the evidence, and how it pairs with oral minoxidil.

SGLT2 inhibitors were developed for diabetes. Their cardiorenal protection data is among the most impressive of any drug class in the last decade — and researchers think the longevity implications go further.

Both raise testosterone. One works with your body. One replaces it entirely. Here's the practical guide to choosing.