Immune / Inflammation
Low Dose Naltrexone (LDN)
Immune modulation and inflammation control. Most popular starter protocol.
vs. AgelessRx $25/mo
Get Started — $19/moCancel anytime. No contracts.
Our price
$19/mo
AgelessRx
$25/mo
You save
24%
Rx review
24–48 hrs
What you get
- Physician evaluation and prescription
- LDN 1.5–4.5mg capsules (30-day supply)
- Dispensed by licensed U.S. compounding pharmacy
- Secure messaging with your physician
- Annual renewal included
How to take it
Taken nightly before bed. Standard starting dose is 1.5mg, titrating up to 4.5mg over 4–6 weeks. Most patients notice changes in sleep quality and energy within 2–4 weeks.
The science
LDN's mechanism centers on transient opioid receptor blockade. This brief blockade triggers a compensatory upregulation of endogenous opioids (endorphins/enkephalins) and modulates microglial activation — the brain's primary inflammatory cells. Multiple peer-reviewed studies support its use in fibromyalgia, Crohn's disease, MS, and chronic pain.
About Low Dose Naltrexone (LDN)
Low dose naltrexone (1.5–4.5mg nightly) is one of the most cost-effective interventions in longevity medicine. At sub-therapeutic doses, LDN transiently blocks opioid receptors, triggering a rebound increase in endorphin production and down-regulating inflammatory cytokines. Used by longevity physicians for autoimmune conditions, chronic fatigue, and general immune optimization.
Common questions
Is LDN FDA-approved?
Naltrexone at 50mg is FDA-approved for opioid and alcohol use disorder. LDN (low dose) is prescribed off-label, which is standard practice — the same medication, a fraction of the dose.
Will LDN interact with other medications?
LDN has interactions with opioid medications (they should not be combined). Your physician will review your medication list during intake.
How soon will I notice effects?
Most patients report changes in sleep and energy within 2–4 weeks. Anti-inflammatory effects may take 6–8 weeks to fully develop.
Low Dose Naltrexone (LDN) — $19/month.
Prescribed by a licensed physician. Ships to your door.
Get StartedCancel anytime. No contracts.