Men & Women
Core Cardio & ED Prevention
The baseline cardiovascular protocol nearly every adult over 40 should consider.
vs. Hims $40/mo
Add to My ProtocolOr build a full protocol with multiple stacks.
Note: Tadalafil is prescribed here as a cardiovascular agent — reducing arterial stiffness and improving endothelial function. It also works for ED in men. Both uses are real; the CV evidence is what puts it in a longevity protocol.
Price comparison
| The Longevity Agent | $29/mo |
| HimsTadalafil only — no statin | $40/mo |
| RomanTadalafil only — no statin | $40/mo |
| BluechewTadalafil only — no statin | $30/mo |
| Hone HealthSeparate statin/tadalafil Rx + membership | $129/mo |
Prices verified April 2026.
Our price
$29/mo
Hims
$40/mo
Evidence
Tier 1
Medications
2
About this stack
Most people know tadalafil for erectile dysfunction. The cardiovascular evidence is what puts it in a longevity protocol: daily low-dose tadalafil reduces arterial stiffness, improves endothelial function, and lowers pulmonary arterial pressure — benefits that are independent of its sexual effects. Atorvastatin 20mg is the most-prescribed statin in the world, with robust cardiovascular event reduction data across multiple large trials. Together they form the baseline cardiovascular protocol most longevity physicians prescribe.
The science
Atorvastatin is the world's most prescribed statin, with extensive real-world safety data and 39–50% LDL reduction at 20mg. The CARDS trial showed atorvastatin reduced major cardiovascular events by 37% in patients with no prior cardiac history. Multiple studies show daily tadalafil reduces arterial stiffness and improves endothelial function — the same PDE5 mechanism that dilates penile vasculature benefits systemic vasculature. High-dose tadalafil (Adcirca) is FDA-approved for pulmonary arterial hypertension. Combination statin + PDE5 inhibitor protocols are standard at leading longevity clinics.
Common questions
Do I need labs before starting atorvastatin?
Not required to begin. We recommend a lipid panel and liver enzymes within the first 90 days. Your provider will guide you.
Is tadalafil appropriate for women?
Yes. Off-label daily tadalafil in women is prescribed for cardiovascular and pulmonary indications. Your physician will review appropriateness based on your history.
Can I take this if I'm already on a statin?
Note your current statin during intake. Your physician will coordinate to avoid duplication.
Core Cardio & ED Prevention — $29/month.
Prescribed by a licensed provider. Ships to your door.
Cancel anytime. No contracts.