Men & Women
Core Cardio & ED Prevention
The baseline cardiovascular protocol nearly every adult over 40 should consider.
vs. Hims $40/mo
Add to My ProtocolOr build a full protocol with multiple stacks.
Note: Tadalafil is prescribed here as a cardiovascular agent — reducing arterial stiffness and improving endothelial function. It also works for ED in men. Both uses are real; the CV evidence is what puts it in a longevity protocol.
Price comparison
| The Longevity Agent | {{PRICE}} |
| HimsTadalafil only — no statin | $40/mo |
| RomanTadalafil only — no statin | $40/mo |
| BluechewTadalafil only — no statin | $30/mo |
| Hone HealthSeparate statin/tadalafil Rx + membership | $129/mo |
Prices verified April 2026.
Competitor price
$129/mo
Rx review
24–48 hrs
Evidence
Tier 1
Medications
2
About this stack
Most people know tadalafil for erectile dysfunction. The under-discussed story is its cardiovascular profile: daily low-dose tadalafil reduces arterial stiffness, improves endothelial function, and lowers pulmonary arterial pressure. That's why longevity physicians prescribe it even to patients without ED — and why it belongs in a cardioprotective stack. Rosuvastatin pairs with it as the most potent statin per milligram, with 44% cardiovascular event reduction in the JUPITER trial. Together they form the baseline cardiovascular protocol most longevity physicians prescribe.
The science
The JUPITER trial demonstrated rosuvastatin reduced major cardiovascular events by 44% in patients with elevated CRP. Multiple studies show daily tadalafil reduces arterial stiffness and improves endothelial function independent of its sexual effects — the same PDE5 mechanism that dilates penile vasculature also benefits systemic vasculature. High-dose tadalafil (Adcirca) is FDA-approved for pulmonary arterial hypertension. Combination statin + PDE5 inhibitor protocols are standard at leading longevity clinics.
Common questions
Do I need labs before starting rosuvastatin?
Not required to begin. We recommend a lipid panel and liver enzymes within the first 90 days. Your physician will guide you.
Is tadalafil appropriate for women?
Yes. Off-label daily tadalafil in women is prescribed for cardiovascular and pulmonary indications. Your physician will review appropriateness based on your history.
Can I take this if I'm already on a statin?
Note your current statin during intake. Your physician will coordinate to avoid duplication.
Core Cardio & ED Prevention.
Prescribed by a licensed provider. Ships to your door.
Cancel anytime. No contracts.