Men & Women
Inflammation
Low-dose naltrexone for systemic inflammation.
vs. AgelessRx $25/mo
Add to My ProtocolOr build a full protocol with multiple stacks.
Price comparison
| The Longevity Agent | $19/mo |
| AgelessRx | $25/mo |
| Defy Medical | $75/mo |
| LifeExtension MD | $79/mo |
Prices verified April 2026.
Our price
$19/mo
Competitor price
$89/mo
You save
79%
Rx review
24–48 hrs
About this stack
This is not addiction medicine. At the 50mg dose FDA-approved for opioid and alcohol use disorder, naltrexone blocks opioid receptors all day. At 1.5–4.5mg — about 1/10th of that dose, taken at night — it briefly blocks receptors for 4–6 hours, then the block releases. The body responds by upregulating its own endorphin production and downregulating inflammatory signaling. Completely different mechanism, completely different indication. Longevity physicians prescribe it for systemic inflammation, autoimmune conditions, and chronic fatigue.
The science
LDN's mechanism centers on transient opioid receptor blockade. The brief nighttime blockade triggers compensatory upregulation of endogenous opioids and modulates microglial activation (the brain's inflammatory cells). Multiple peer-reviewed trials support its use in fibromyalgia, Crohn's disease, MS, and ME/CFS. The anti-inflammatory mechanism is conserved across conditions. Not immunosuppressive — immunomodulatory.
Common questions
Is LDN FDA-approved?
Naltrexone at 50mg is FDA-approved for opioid and alcohol use disorder. LDN is prescribed off-label — the same medication, a fraction of the dose, with a different mechanism at low doses.
Can I take LDN if I'm on opioids?
No. LDN is contraindicated with opioid medications. Your physician will review your medication list.
How soon will I notice effects?
Most patients report changes in energy and sleep quality within 2–4 weeks. Anti-inflammatory effects may take 6–8 weeks to fully develop.
What is the cheapest place to get LDN (low dose naltrexone) online?
The Longevity Agent offers LDN at $19/month — cheaper than AgelessRx ($25–$89/mo) and every other major telehealth platform. Price includes physician evaluation and prescription.
How does The Longevity Agent compare to AgelessRx for LDN?
The Longevity Agent charges $19/month for LDN. AgelessRx charges $25–$89/month for equivalent therapy. Both include physician evaluation. No membership fees at either.
Inflammation — $19/month.
Prescribed by a licensed provider. Ships to your door.
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