Men & Women
Longevity Base
The three drugs with the strongest evidence for slowing aging.
vs. Healthspan $100/mo
Add to My ProtocolOr build a full protocol with multiple stacks.
Price comparison
| The Longevity Agent | $59/mo |
| AgelessRxRapamycin $65 + metformin $25 + acarbose $55 | $145/mo |
| HealthspanRapamycin $70 + metformin $30 (no acarbose) | $100/mo |
| OptispanRapamycin $99 + est. metformin/acarbose | $154/mo |
Prices verified April 2026.
Our price
$59/mo
Competitor price
$249/mo
You save
76%
Pathways
3
About this stack
The protocol most longevity physicians use themselves. Rapamycin inhibits mTORC1 — the only drug to consistently extend lifespan in multiple mammalian species. Metformin activates AMPK, mimicking caloric restriction. Acarbose reduces post-meal glucose spikes and has extended lifespan in ITP mouse studies. Together they cover three distinct aging pathways.
The science
Rapamycin extended median lifespan in ITP mice by 9–14%, even when started in old age. Metformin is being studied in the landmark TAME trial as a geroprotective agent. Acarbose showed significant lifespan extension in male ITP mice — one of the few drugs to show benefit in the NIA's rigorous testing program. Together they hit mTOR, AMPK, and glucose signaling.
Common questions
Is rapamycin safe at longevity doses?
At 2–6mg once weekly, rapamycin's immunosuppressive effects are minimal. Thousands of patients have used this protocol over 5–10 years without alarming safety signals.
Does metformin blunt exercise adaptation?
Some data suggests modest reduction in mitochondrial adaptation to resistance training. Your physician can advise on timing relative to workouts.
What is acarbose doing in this stack?
Acarbose slows carbohydrate digestion, blunting post-meal glucose spikes. It's one of the few drugs to show lifespan extension in NIA ITP mouse studies — particularly in males.
What is the cheapest place to get rapamycin prescribed online?
The Longevity Agent offers the Longevity Base stack (rapamycin + metformin + acarbose) for $59/month — vs AgelessRx at ~$145/mo and Healthspan at ~$100/mo. Price includes physician evaluation and prescription.
How does The Longevity Agent compare to AgelessRx for rapamycin?
The Longevity Agent: $59/month for rapamycin + metformin + acarbose. AgelessRx: approximately $145/month for an equivalent protocol. Both are physician-prescribed. The Longevity Agent saves you ~59%.
Longevity Base — $59/month.
Prescribed by a licensed provider. Ships to your door.
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