Men & Women
Skin
FDA-approved for acne. Used by longevity physicians for the strongest anti-aging evidence in topical skincare.
vs. Dermatica $20/mo
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Price comparison
| The Longevity Agent | {{PRICE}} |
| Apostrophe | $30/mo |
| Curology | $25/mo |
| Musely | $35/mo |
| Dermatica | $20/mo |
Prices verified April 2026.
Evidence
30+ years
Competitor price
$79/mo
Delivery
Topical cream
Application
Nightly
About this stack
Tretinoin was FDA-approved for acne. That's the regulatory history. What put it in every longevity physician's protocol is the anti-aging evidence: tretinoin is the only topical ingredient with randomized controlled trial data showing reversal of photoaging — not prevention, actual reversal at the histological level. Unlike OTC retinols that must be converted to retinoic acid by skin enzymes (an inefficient, variable process), tretinoin is retinoic acid and works directly. Over 30 years of literature, confirmed by biopsy.
The science
Tretinoin increases collagen synthesis, accelerates skin cell turnover, and reverses photoaging at the histological level. A landmark 48-week randomized trial published in NEJM showed visible reversal of fine lines, improved skin texture, and increased dermal collagen in tretinoin-treated vs placebo skin.
Common questions
How do I use tretinoin without irritation?
Start with a pea-sized amount every 2–3 nights on dry skin. Increase frequency as tolerated. Moisturizer over tretinoin reduces irritation. Your physician will guide the titration.
When do I see results?
Initial purging (if any) resolves in 4–6 weeks. Texture improvement is typically noticeable at 8–12 weeks. Maximum anti-aging effects at 6–12 months.
Can I use this with other actives (vitamin C, AHAs)?
Generally yes, but separate your actives from tretinoin (different times of day). Your physician will advise based on your skin routine.
Skin.
Prescribed by a licensed provider. Ships to your door.
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