Apigenin
4',5,7-Trihydroxyflavone
Inhibits CD38, the primary NAD+-consuming enzyme, preserving intracellular NAD+ levels. Also activates SIRT3.
Typical longevity dose: 50-500 mg/day
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
Swanson Apigenin 50mg 50mg · capsule · 90 servings | Swanson Vitamins | $8.99 | $0.10 | 7 | Buy |
Swanson Apigenin 50mg 50mg · capsule · 90 servings | Amazon⚠ | $9.49 | $0.11 | 2 | Buy |
Nootropics Depot Apigenin 50mg 50mg · capsule · 120 servings | Nootropics Depot | $14.99 | $0.12 | 9 | Buy |
Momentous Apigenin 50mg 50mg · capsule · 60 servings | Momentous | $29.95 | $0.50 | 8 | Buy |
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Key Research
Apigenin inhibits CD38, nearly doubling liver NAD+ levels in mice.
Escande C, et al. (2013). Diabetes
Interaction Warnings
Sedatives
May cause additive sedation
Synergies
Nicotinamide Riboside
NR provides NAD+ precursor while apigenin prevents degradation
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.