All Supplements

5-Methyltetrahydrofolate

Typical dose: 400-1000 mcg/day

Bioactive form of folate bypassing MTHFR enzyme. Critical methyl donor for DNA synthesis and repair.

3 products compared

L-Alpha glycerylphosphorylcholine

Typical dose: 300-600 mg/day

Highly bioavailable choline source that crosses blood-brain barrier. Precursor to acetylcholine, the neurotransmitter critical for memory, focus, and muscle contraction.

3 products compared

4',5,7-Trihydroxyflavone

Typical dose: 50-500 mg/day

Inhibits CD38, the primary NAD+-consuming enzyme, preserving intracellular NAD+ levels. Also activates SIRT3.

3 products compared

Withania somnifera

Typical dose: 300-600 mg/day (standardized extract)

Adaptogen that modulates cortisol, reduces stress-related biomarkers, and may support telomere length via telomerase activation. KSM-66 and Sensoril are clinically studied extracts.

4 products compared

3,3'-dihydroxy-beta,beta-carotene-4,4'-dione

Typical dose: 4-12 mg/day

Embeds into cellular and mitochondrial membranes, neutralizing oxidative stress. Activates Nrf2 antioxidant pathway.

3 products compared

Berberine hydrochloride

Typical dose: 500-1500 mg/day (divided doses)

Activates AMPK (cellular energy sensor), mimicking some effects of caloric restriction. Improves insulin sensitivity, lowers blood glucose, and modulates gut microbiome.

4 products compared

Boron (as boron glycinate)

Typical dose: 3-6 mg/day

Trace mineral that supports bone metabolism, cognitive function, and hormonal balance. May increase free testosterone and support vitamin D metabolism.

3 products compared

Calcium 2-oxoglutarate

Typical dose: 1000 mg/day

Substrate for TET enzymes regulating epigenetic age through DNA methylation. Key Krebs cycle intermediate.

2 products compared

Cytidine 5'-diphosphocholine

Typical dose: 250-500 mg/day

Provides both choline and cytidine (converted to uridine). Supports phosphatidylcholine synthesis for cell membranes and acetylcholine production for cognition.

3 products compared

Coenzyme Q10 (Ubiquinone/Ubiquinol)

Typical dose: 100-300 mg/day (ubiquinol preferred for absorption)

Essential electron carrier in mitochondrial ATP production. Ubiquinol (reduced form) is a potent lipid-soluble antioxidant. Levels decline ~50% by age 80.

4 products compared

Hydrolyzed collagen (Types I & III)

Typical dose: 10-20 g/day

Hydrolyzed collagen provides bioactive peptides that stimulate fibroblast collagen synthesis, supporting skin elasticity, joint health, and gut lining integrity.

4 products compared

N-(aminoiminomethyl)-N-methylglycine

Typical dose: 3-5 g/day

Increases phosphocreatine stores for rapid ATP regeneration. Supports muscle strength, cognitive function, and neuroprotection. One of the most studied supplements.

5 products compared

L-Ergothioneine

Typical dose: 5-25 mg/day

Amino acid with a dedicated cellular transporter (OCTN1), suggesting evolutionary importance. Accumulates in mitochondria to protect against oxidative damage.

2 products compared

3,3',4',7-Tetrahydroxyflavone

Typical dose: 100-500 mg/day

Potent senolytic that eliminates senescent cells by targeting PI3K/AKT/mTOR pathway and BCL-2 family anti-apoptotic proteins.

3 products compared

Glucosamine sulfate / HCl

Typical dose: 1500 mg/day

Amino sugar that serves as building block for glycosaminoglycans in cartilage. May slow cartilage degradation and has emerging evidence for longevity via hexosamine pathway.

3 products compared

Aminoacetic acid

Typical dose: 3-5 g/day

Simplest amino acid with multiple longevity roles: supports collagen synthesis, acts as inhibitory neurotransmitter (sleep), precursor to glutathione, and may mimic methionine restriction.

3 products compared

Hyaluronan

Typical dose: 100-200 mg/day

Maintains extracellular matrix hydration and supports skin elasticity and joint lubrication.

2 products compared

L-gamma-glutamylethylamide

Typical dose: 100-400 mg/day

Amino acid from tea that crosses the blood-brain barrier. Increases alpha brain waves promoting calm focus. Modulates GABA, serotonin, and dopamine.

3 products compared

Hericium erinaceus

Typical dose: 500-3000 mg/day (fruiting body extract)

Medicinal mushroom containing hericenones and erinacines that stimulate Nerve Growth Factor (NGF) synthesis. Supports neuroplasticity, memory, and cognitive function.

3 products compared

Methylsulfonylmethane

Typical dose: 1000-3000 mg/day

Organic sulfur compound that supports connective tissue, reduces inflammation, and provides sulfur for glutathione synthesis.

3 products compared

Magnesium bis(2-aminoacetate)

Typical dose: 200-400 mg elemental magnesium/day

Highly bioavailable magnesium chelated to glycine. Cofactor for 300+ enzymatic reactions.

4 products compared

N-Acetyl-5-methoxytryptamine

Typical dose: 0.3-5 mg/day (lower doses often more effective)

Hormone produced by the pineal gland that regulates circadian rhythm. Also a potent antioxidant that accumulates in mitochondria. Production declines with age.

3 products compared

N-Acetyl-L-Cysteine

Typical dose: 600-1800 mg/day

Precursor to glutathione, the body's master antioxidant. Supports liver detoxification, reduces oxidative stress, and has mucolytic properties.

4 products compared

beta-Nicotinamide mononucleotide

Typical dose: 250-1000 mg/day

NAD+ precursor via the salvage pathway. Converted to NAD+ by NMNAT enzymes. Research suggests oral NMN effectively elevates NAD+ in humans.

2 products compared

Nicotinamide

Typical dose: 500-1500 mg/day

Amide form of niacin that does not cause flushing. NAD+ precursor via the salvage pathway. Supports skin health, DNA repair, and cellular energy production.

3 products compared

Nicotinamide riboside chloride

Typical dose: 300-1000 mg/day

NAD+ precursor converted via NR kinase pathway. Elevates NAD+, activating sirtuins (SIRT1, SIRT3) and PARPs for DNA repair.

3 products compared

Eicosapentaenoic acid / Docosahexaenoic acid

Typical dose: 2000-4000 mg combined EPA/DHA per day

EPA and DHA incorporate into cell membranes, modulating inflammation via specialized pro-resolving mediators. DHA is critical for brain structure.

4 products compared

Pyrroloquinoline quinone disodium salt

Typical dose: 10-20 mg/day

Stimulates mitochondrial biogenesis via PGC-1alpha activation. Potent antioxidant (up to 5000x the redox cycling capacity of vitamin C). Supports neuronal growth factors.

3 products compared

Inulin / Galactooligosaccharides

Typical dose: 5-10 g/day (start low, increase gradually)

Non-digestible fibers that selectively feed beneficial gut bacteria (Bifidobacteria, Lactobacillus). Promote short-chain fatty acid production including butyrate.

3 products compared

3,3',4',5,7-Pentahydroxyflavone

Typical dose: 500-1000 mg/day

Induces apoptosis in senescent cells by inhibiting pro-survival pathways (PI3K/AKT, BCL-2 family). Also inhibits COX-2, NF-kB, and MAPK inflammatory pathways.

4 products compared

Rhodiola rosea

Typical dose: 200-600 mg/day (3% rosavins extract)

Adaptogen that modulates stress response via HPA axis regulation. Contains rosavins and salidroside which support mental performance, reduce fatigue, and may have antidepressant effects.

3 products compared

L-Selenomethionine

Typical dose: 100-200 mcg/day

Essential trace mineral incorporated into selenoproteins including glutathione peroxidase. Critical for thyroid function, antioxidant defense, and DNA repair.

3 products compared

N-(3-aminopropyl)butane-1,4-diamine

Typical dose: 1-6 mg/day

Potent inducer of autophagy. Promotes cellular recycling of damaged organelles and misfolded proteins.

2 products compared

Betaine anhydrous

Typical dose: 500-1500 mg/day

Methyl donor that converts homocysteine to methionine via BHMT. Provides methyl groups consumed during NR/NMN metabolism.

3 products compared

2-Aminoethanesulfonic acid

Typical dose: 1-3 g/day

Conditionally essential amino acid that declines with age. Supports mitochondrial function, acts as osmolyte for cell volume regulation, and has anti-inflammatory and antioxidant properties.

4 products compared

1,7-bis(4-hydroxyphenyl)heptane-3,5-dione

Typical dose: 250-500 mg/day

Active metabolite of curcumin with superior bioavailability. Potent anti-inflammatory via NF-kB inhibition.

2 products compared

Glyceryl tributyrate

Typical dose: 300-1000 mg/day

Pro-drug delivering butyrate to the colon. Primary energy source for colonocytes, maintains gut barrier integrity.

2 products compared

Methylcobalamin

Typical dose: 1000-5000 mcg/day

Active form of B12 directly usable as a methyl donor. Essential for homocysteine metabolism and neurological function.

3 products compared

Pyridoxal-5-Phosphate

Typical dose: 25-100 mg/day as P-5-P

Active form of B6 serving as cofactor for 150+ enzymatic reactions. Essential for neurotransmitter synthesis and homocysteine metabolism.

2 products compared

L-Ascorbic Acid

Typical dose: 500-2000 mg/day

Essential antioxidant and cofactor for collagen synthesis, immune function, and iron absorption. Supports glutathione recycling and may help maintain telomere length.

4 products compared

Cholecalciferol

Typical dose: 2000-5000 IU/day

Converted to calcitriol which binds VDR to regulate 200+ genes. Modulates immune function, reduces inflammation, protects telomere length.

4 products compared

Menaquinone-7

Typical dose: 100-200 mcg/day

Activates Matrix Gla Protein and osteocalcin, directing calcium away from arteries into bones.

4 products compared

Zinc (various chelates)

Typical dose: 15-30 mg/day

Essential mineral and cofactor for 300+ enzymes. Critical for immune function, DNA synthesis, wound healing, and thymic function. Zinc picolinate and bisglycinate offer best absorption.

3 products compared