Berberine
Berberine hydrochloride
Activates AMPK (cellular energy sensor), mimicking some effects of caloric restriction. Improves insulin sensitivity, lowers blood glucose, and modulates gut microbiome.
Typical longevity dose: 500-1500 mg/day (divided doses)
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
Nutricost Berberine HCl 500mg 500mg · capsule · 120 servings | Nutricost | $14.95 | $0.12 | 6 | Buy |
NOW Berberine Glucose Support 400mg 400mg · capsule · 90 servings | iHerb | $19.99 | $0.22 | 8 | Buy |
NOW Berberine Glucose Support 400mg 400mg · capsule · 90 servings | NOW Foods | $21.99 | $0.24 | 7 | Buy |
Life Extension Berberine 500mg 500mg · capsule · 60 servings | Life Extension | $16.50 | $0.28 | 9 | Buy |
Thorne Berberine 1000mg 1000mg · capsule · 60 servings | Thorne | $36.00 | $0.60 | 9 | Buy |
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Key Research
Berberine lowered HbA1c comparably to metformin in type 2 diabetics.
Yin J, et al. (2008). Metabolism
Interaction Warnings
Metformin
Additive blood sugar lowering — monitor glucose
CYP3A4 substrates
Inhibits CYP3A4 and CYP2D6
Synergies
Alpha-Lipoic Acid
Both support insulin sensitivity
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.