DIM (Diindolylmethane)
3,3'-Diindolylmethane (DIM)
Metabolite of indole-3-carbinol from cruciferous vegetables; shifts estrogen metabolism toward favorable 2-hydroxy metabolites over 16-alpha and 4-hydroxy; supports hormone balance and cellular health
Typical longevity dose: 100-200 mg/day
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
NOW Foods DIM 200mg 90 Capsules 200mg · capsule · 90 servings | iHerb | $17.44 | $0.19 | 8 | Buy |
Nature's Way DIM-Plus 120 Capsules 100mg · capsule · 60 servings | iHerb | $15.65 | $0.26 | 8 | Buy |
Thorne Hormone Advantage (DIM + SGS) 60 Capsules 100mg · capsule · 60 servings | iHerb | $51.00 | $0.85 | 8 | Buy |
Thorne Hormone Advantage (DIM + SGS) 60 Capsules 100mg · capsule · 60 servings | Thorne | $51.00 | $0.85 | 9 | Buy |
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Key Research
DIM supplementation favorably altered estrogen metabolite ratios (2:16 ratio) in postmenopausal women
Thomson CA et al. (2017). Cancer Prevention Research
DIM at 108mg daily significantly increased urinary 2-hydroxyestrone levels in both men and women
Dalessandri KM et al. (2004). Journal of Nutrition
Interaction Warnings
Hormone-sensitive medications
DIM alters estrogen metabolism; may affect hormone therapies, birth control, or tamoxifen
CYP1A2 substrates
DIM may induce CYP1A2 enzyme, affecting metabolism of caffeine and certain medications
Synergies
Sulforaphane
Complementary cruciferous compounds; DIM modulates estrogen metabolism while sulforaphane activates Nrf2 detoxification
Calcium D-Glucarate
D-Glucarate inhibits beta-glucuronidase, preventing reabsorption of estrogen conjugates that DIM helps form
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.