Glutathione
L-Glutathione (reduced form, GSH)
Master endogenous antioxidant; tripeptide (glutamate-cysteine-glycine) that neutralizes ROS, regenerates vitamins C and E, supports phase II liver detoxification via conjugation, and modulates immune cell function
Typical longevity dose: 250-500 mg/day (liposomal preferred for bioavailability)
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
NOW Foods Glutathione 500mg with Milk Thistle & ALA 60 Capsules 500mg · capsule · 60 servings | iHerb | $14.68 | $0.24 | 8 | Buy |
Jarrow Formulas Reduced Glutathione 500mg 60 Capsules 500mg · capsule · 60 servings | iHerb | $36.70 | $0.61 | 8 | Buy |
Thorne Glutathione-SR 175mg 60 Capsules 175mg · capsule · 60 servings | iHerb | $54.00 | $0.90 | 8 | Buy |
Pure Encapsulations Liposomal Glutathione 375mg 30 Softgels 375mg · softgel · 30 servings | iHerb | $39.60 | $1.32 | 8 | Buy |
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Key Research
Oral glutathione supplementation (250-1000mg) increased body stores of GSH and reduced oxidative stress markers
Richie JP et al. (2015). European Journal of Nutrition
Liposomal glutathione had superior bioavailability vs standard oral GSH, increasing blood GSH levels 40%
Sinha R et al. (2018). Clinical Pharmacology & Therapeutics
Interaction Warnings
Chemotherapy drugs
Glutathione may reduce efficacy of some chemo agents that rely on oxidative damage to kill cancer cells; consult oncologist
Acetaminophen
Glutathione detoxifies the hepatotoxic metabolite NAPQI from acetaminophen
Synergies
NAC (N-Acetyl Cysteine)
NAC provides the rate-limiting cysteine precursor for endogenous glutathione synthesis
Alpha-Lipoic Acid
ALA regenerates oxidized glutathione back to its reduced (active) form
Vitamin C
Vitamin C recycles glutathione; both work in tandem in the antioxidant network
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.