Milk Thistle / Silymarin
Silymarin (from Silybum marianum)
Flavonolignan complex (silybin, silydianin, silychristin) that protects hepatocytes by stabilizing cell membranes, stimulating protein synthesis for liver regeneration, and scavenging free radicals; inhibits NF-kB inflammatory signaling
Typical longevity dose: 150-600 mg silymarin/day
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
Jarrow Formulas Milk Thistle 150mg 200 Capsules 150mg · capsule · 200 servings | Jarrow Formulas | $19.99 | $0.10 | 8 | Buy |
NOW Foods Milk Thistle Extract 300mg (240mg Silymarin) 200 Capsules 300mg · capsule · 200 servings | iHerb | $21.99 | $0.11 | 8 | Buy |
Life Extension Advanced Milk Thistle 120 Softgels 270mg · softgel · 120 servings | iHerb | $21.00 | $0.17 | 8 | Buy |
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Key Research
Silymarin demonstrated hepatoprotective effects in NAFLD patients, reducing liver enzyme levels and improving steatosis
Abenavoli L et al. (2018). Phytotherapy Research
Silymarin has well-documented clinical efficacy for toxic and alcoholic liver disease
Saller R et al. (2001). Drugs
Interaction Warnings
CYP2C9 substrates (warfarin)
Milk thistle may mildly inhibit CYP2C9, potentially increasing levels of warfarin and NSAIDs
Diabetes medications
Silymarin may lower blood sugar; monitor if on hypoglycemic drugs
Synergies
NAC
Both support liver detoxification through complementary pathways - silymarin protects hepatocytes while NAC provides glutathione precursor
Artichoke extract
Both support bile flow and liver function; often combined in liver support formulas
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.