Nattokinase
Nattokinase (EC 3.4.21.62, from Bacillus subtilis var. natto)
Fibrinolytic serine protease enzyme that directly degrades fibrin clots; also converts pro-urokinase to active urokinase, enhancing the body's own clot-dissolving cascade; reduces blood viscosity
Typical longevity dose: 2000-4000 FU/day (100-200mg)
Price Comparison
| Product | Vendor | Price | Per Serving | Trust | |
|---|---|---|---|---|---|
Doctor's Best Nattokinase 2000 FU 270 Capsules 100mg · capsule · 270 servings | iHerb | $36.99 | $0.14 | 8 | Buy |
NOW Foods Nattokinase 100mg 2000 FU 120 Capsules 100mg · capsule · 120 servings | iHerb | $18.36 | $0.15 | 8 | Buy |
Doctor's Best Nattokinase 2000 FU 90 Capsules 100mg · capsule · 90 servings | iHerb | $14.99 | $0.17 | 8 | Buy |
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Key Research
Nattokinase reduced fibrinogen, factor VII, and factor VIII levels, showing potent fibrinolytic activity
Jensen GS et al. (2016). Alternative Therapies in Health and Medicine
Nattokinase supplementation reduced systolic and diastolic blood pressure in hypertensive subjects
Kim JY et al. (2008). Hypertension Research
Interaction Warnings
Blood thinners (warfarin, aspirin)
Nattokinase has significant fibrinolytic activity; combining with anticoagulants dramatically increases bleeding risk
Antiplatelet drugs
Additive blood-thinning effects; discontinue 2 weeks before surgery
Synergies
Serrapeptase
Complementary proteolytic enzymes; nattokinase targets fibrin while serrapeptase targets other inflammatory proteins
Omega-3 fish oil
Both support cardiovascular function; omega-3s reduce inflammation while nattokinase improves blood flow
Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.