nrf2-activationdetoxificationanti-inflammatoryanti-cancer

Sulforaphane / Broccoli Sprout Extract

Sulforaphane (from Glucoraphanin + Myrosinase)

Potent Nrf2 activator that upregulates phase II detoxification enzymes and antioxidant response element (ARE) genes; supports liver detox, reduces inflammation, and has anti-cancer properties

Typical longevity dose: 10-50 mg sulforaphane/day (or equivalent SGS)

Price Comparison

ProductVendorPricePer ServingTrust

Swanson Sulforaphane from Broccoli Sprout Extract 400mcg 60 Capsules

0.4mg · capsule · 60 servings

iHerb$7.64$0.138Buy

Jarrow Formulas BroccoMax 35mg SGS 120 Capsules

35mg · capsule · 120 servings

iHerb$23.85$0.208Buy

Jarrow Formulas BroccoMax 35mg SGS 120 Capsules

35mg · capsule · 120 servings

Jarrow Formulas$43.99$0.378Buy

Thorne Broccoli Seed Extract (Crucera-SGS) 60 Capsules

50mg · capsule · 60 servings

Thorne$38.00$0.639Buy

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Key Research

Sulforaphane is the most potent natural Nrf2 inducer, activating over 200 cytoprotective genes

Houghton CA et al. (2013). Oxidative Medicine and Cellular Longevity

Sulforaphane bioavailability is 7x higher when myrosinase enzyme is present in the supplement

Fahey JW et al. (2017). Nutrients

Interaction Warnings

CYP1A2 substrates

Sulforaphane induces CYP1A2, potentially affecting caffeine and some drug metabolism

Thyroid (goitrogens)

Cruciferous compounds may slightly affect thyroid in iodine-deficient individuals at very high doses

Synergies

DIM

DIM and sulforaphane together support complementary estrogen metabolism pathways

Glutathione / NAC

Sulforaphane upregulates glutathione synthesis; NAC provides the cysteine substrate

Disclaimer: This information is for educational purposes only and is not medical advice. Research citations are provided for reference — consult your healthcare provider before starting any supplement regimen. Prices are estimates and may not reflect current retail pricing.