Bryan Johnson's Blueprint
Comprehensive longevity optimization
Bryan Johnson's publicly shared supplement protocol from his Blueprint longevity program. Johnson spends over $2M/year on his anti-aging regimen. This represents the supplement portion of his stack that is available over-the-counter.
Not affiliated
This is Bryan Johnson's published protocol. We are not affiliated with them. We just make it easy to shop their stack at the best prices.
Dosing Notes
Johnson's protocol is highly specific with exact timing. Most supplements taken with breakfast. NR + TMG together in the morning. D3+K2 with fat-containing meal. This is a simplified representation — see blueprint.bryanjohnson.com for his full protocol.
Life Extension NAD+ Cell Regenerator 300mg
300mg · capsule · 30 servings
via Life Extension$34.50
$1.15/serving
$11.49
$0.11/serving
$14.00
$0.23/serving
$18.00
$0.20/serving
Life Extension Super Omega-3 EPA/DHA
2000mg · softgel · 120 servings
via Life Extension$24.75
$0.21/serving
Momentous Creatine Monohydrate 5g (Creapure)
5000mg · powder · 60 servings
via Momentous$29.95
$0.50/serving
Life Extension Super Ubiquinol CoQ10 100mg
100mg · softgel · 60 servings
via Life Extension$33.00
$0.55/serving
$6.75
$0.07/serving
$14.99
$0.17/serving
Life Extension Curcumin Elite 500mg
500mg · capsule · 60 servings
via Life Extension$22.50
$0.38/serving
Total stack cost (cheapest per product)
$234.67
Interaction Warnings
Nicotinamide Riboside
- • Methyl donors: Consumes methyl groups — pair with TMG
Vitamin D3
- • Thiazide diuretics: May cause hypercalcemia
Vitamin K2 (MK-7)
- • Warfarin: Vitamin K directly antagonizes warfarin — DO NOT combine
Omega-3 (EPA/DHA)
- • Anticoagulants: High-dose omega-3 may increase bleeding risk
Vitamin C
- • Iron supplements: Enhances iron absorption — beneficial for deficiency, caution in iron overload
CoQ10 / Ubiquinol
- • Statins: Statins deplete CoQ10 — supplementation recommended
- • Warfarin: May reduce warfarin efficacy
Zinc
- • Copper: Long-term zinc supplementation can deplete copper — consider adding 1-2 mg copper
Ashwagandha
- • Thyroid medications: May increase thyroid hormone levels
- • Immunosuppressants: May stimulate immune system
Tetrahydrocurcumin
- • Anticoagulants: Mild anti-platelet effects
This is not medical advice. Consult your healthcare provider before starting any supplement regimen.